VIAGRA is a drug for the treatment of erectile dysfunction – erectile dysfunction. Acts on the natural mechanisms of erection. It is used in men suffering from erectile dysfunction of various origins (vascular, nervous disorders of erection) 비아그라 구입.
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) 비아그라 구입.
The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.
Nitric oxide activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate (cGMP), relaxation of the smooth muscles of the cavernous body and increased blood flow in the penis 비아그라 구입.
Sildenafil does not have a direct relaxing effect on the isolated human corpus cavernosum, but actively enhances the relaxing effect of NO on this tissue by inhibiting PDE5, which is responsible for the breakdown of cGMP in the corpus cavernosum.
During sexual arousal, the local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in the level of cGMP in the cavernous body, resulting in smooth muscle relaxation and increased blood flow in the cavernous body.
A prerequisite for the effectiveness of sildenafil is sexual stimulation.
Treatment of erectile dysfunction characterized by an inability to achieve or maintain an erection of the penis sufficient for satisfactory intercourse.
Viagra is effective only in the presence of sexual stimulation.
Use during pregnancy and lactation
Not intended for use in women.
- Hypersensitivity to any component of the drug.
- Use in patients receiving constantly or intermittently nitric oxide donators, organic nitrates or nitrites in any form.
- Age up to 18 years.
- Not intended for use in women.
With caution: anatomical deformity of the penis (including angulation, cavernous fibrosis or Peyronne’s disease), diseases predisposing to the development of priapism (such as sickle cell anemia, multiple myeloma, leukemia, thrombocythemia), diseases accompanied by bleeding, exacerbation of peptic ulcer diseases, hereditary retinitis pigmentosa, heart failure, unstable angina, myocardial infarction, stroke or life-threatening arrhythmias, arterial hypertension (BP> 170/100 mm Hg) or hypotension (BP < 90/50 mm Hg) in the last 6 months Art.).